Old Drugs for New Purpose—Fast Pace Therapeutic Identification for<scp>SARS?CoV</scp>?2 Infections by Pharmacophore Guided Drug Repositioning Approach

The recent outbreak, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating effect globally with no effective treatment. A swift strategy to find therapeutics against disease 2019 (COVID-19) is repurpose the approved drugs blend of computational techniques. In this pursuit an exhaustive methods were applied on DrugBank compounds targeting SARS-CoV-2 main protease (Mpro). structure-based pharmacophore model was generated considering interactions between target and inhibitor N3. validated subjected screen database yielding 35 compounds. Further, evaluating binding affinity studies reference drug Remdesivir resulted six candidates higher molecular dock scores than compound. These have demonstrated firm dynamics simulation (MDS) results forming stable protein-drug complex demonstrating features. Taken together, our findings propose Viomycin, Enviomycin, Framycetin, Amikacin, Iopromide, Paromomycin as potent putative inhibitors for COVID-19 therapeutics.