Olanzapine Loaded Nanostructured Lipid Carriers via High Shear Homogenization and Ultrasonication
نویسندگان
چکیده
The aim of this study was to understand the effect high shear homogenization (HSH) and ultrasonication (US) on physicochemical properties blank olanzapine loaded nanostructured lipid carriers (NLCs) along with their drug loading potential release profiles from formulated particles. NLCs were prepared different ratios Compritol Miglyol as solid liquid lipids, respectively, under changing HSH US times between 0 15 min. surfactants (Poloxamer 188 (P188) tween 80) content kept constant in all formulations. evaluated for particle size, polydispersity index, zeta potential, crystallinity chemical interactions lipids OLZ. in-vitro performed using dialysis tube method phosphate buffer solution (PBS) at pH 7.4. negatively charged, spherically shaped monodisperse, sizes ranging 112 191 nm. There a significant influence time preparation comparison HSH, where reduction mean diameter seen after 5 min sonication. An increase led an size. In general, application decrease size but low containing also observed longer sonication time. OLZ successfully encapsulated total 89% achieved 24 h PBS
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2021
ISSN: ['0036-8709', '2218-0532']
DOI: https://doi.org/10.3390/scipharm89020025