Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
نویسندگان
چکیده
منابع مشابه
Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We explored the relation between paternal age and offspring's LTLs in 4 different cohorts. Moreover, we examined the potential cause of the paternal age on offspring's LTL by deli...
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Telomeres are structures at the ends of DNA strands that get longer in the DNA of sperm [2] cells as males age. That phenomenon is different for most other types of cells, for which telomeres get shorter as organisms age. In 1992, scientists showed that telomere [3] length (TL) in sperm [2] increases with age in contrast to most cell of most other types. Telomeres are the protective caps at the...
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In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
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Telomere length (TL) in humans is highly heritable and undergoes progressive age-dependent shortening in somatic cells. By contrast, sperm donated by older men display comparatively long telomeres, presumably because in the male germline, telomeres become longer with age. This puzzling phenomenon might explain why TL in the offspring correlates positively with paternal age. The present communic...
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Leukocyte telomere length (LTL) is longer in association with advanced paternal age, but this association has not been examined along with family history (FH) in schizophrenia. LTL was measured by PCR and compared across cases and controls as part of a study to examine the characteristics of paternal age related schizophrenia. The 53 schizophrenia cases had similar mean LTL as 20 controls, alth...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2005
ISSN: 1553-7390,1553-7404
DOI: 10.1371/journal.pgen.0040037.eor