Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota
نویسندگان
چکیده
منابع مشابه
Oxantel pamoate-albendazole for Trichuris trichiura infection.
BACKGROUND Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and often occur concomitantly. These parasitic-worm infections are typically treated with albendazole or mebendazole, but both drugs show low efficacy against T. trichiura. Albendazole is the drug of choice against hookworm. METHODS In this double-blind trial conducte...
متن کاملGlobal deworming: moving past albendazole and mebendazole.
Since the 2001 adoption of the World Health Assembly (WHA) resolution calling for the global deworming of children affected by soil-transmitted helminth (STH) infections and schistosomiasis, the world’s public health leaders have gradually responded. Although we are still behind schedule in terms of the WHA’s original 2010 targets, WHO continues to report progress— in 2015, approximately 59% of...
متن کاملActivity of Oxantel Pamoate Monotherapy and Combination Chemotherapy against Trichuris muris and Hookworms: Revival of an Old Drug
BACKGROUND It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses. The re-evaluation of old, forgotten drugs is a promising strategy to identify alternative anthelminthic drug candidates or drug combinations. METHODOLOGY We studied...
متن کاملIntestinal nematode infections and efficacy study of oxantel-pyrantel pamoate among plantation workers.
Pyrantel has been demonstrated (Bumbalo et al., 1969; Desowitz et al., 1970; Hsieh, 1971) to be effective for treatment of Ascaris, hookworm and Enterobuis. Oxantel has been shown (Zaman and Sabapaty, 1975; Garcia, 1976; Lee et al., 1976; Rim et al., 1976) to be effective against Trichuriasis. A combined Oxantel-pyrantel salts has been shown (Rim et al., 1975; Lim, 1978; Dissanaike, 1978; Cabre...
متن کاملStrongyloides ratti: In Vitro and In Vivo Activity of Tribendimidine
BACKGROUND Strongyloidiasis is a truly neglected tropical disease, but its public health significance is far from being negligible. At present, only a few drugs are available for the treatment and control of strongyloidiasis. METHODOLOGY/PRINCIPAL FINDINGS We investigated the activity of tribendimidine against third-stage larvae (L(3)) of Strongyloides ratti in vitro and against juvenile and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal for Parasitology: Drugs and Drug Resistance
سال: 2018
ISSN: 2211-3207
DOI: 10.1016/j.ijpddr.2018.07.001