Off target effects of statins shape total mortality?

Off target effects of statins shape total mortality?

Kazerooni and Lim report several independent predictors of mortality in new start statin users after long-term follow-up [age, race, number of medications, comorbidities, and body mass index (BMI)]; however, differences in lipid groups and adherence to statin treatment after 1 year were not predictive of long-term mortality in the veteran population studied. This may be due to the low adherence...

In Silico Investigation of Off-Target Effects

The effects of statins on mortality rates among bacteremic patients.

Sir—Liappis et al. [1] noted decreased mortality rates among bacteremic patients who were receiving statins, but they were not able to define the mechanisms by which this reduction in the mortality rate occurred. It has recently been proposed that endothelial apoptosis could be the pivotal event in the pathogenesis of systemic inflammatory response syndrome, sepsis, acute respiratory distress s...

Statins target multiple sclerosis

Statins target multiple sclerosis Statins, drugs widely used to lower cholesterol, alleviate symptoms in a mouse model of multiple sclerosis, according to Sawsan Youssef et al. in the 7 November Nature. But there are marked difference between the mouse model and humans, so whether the approach is likely to work in people is still uncertain. In the mice, oral administration of atorvastatin (Lipi...

Off-target cannabinoid effects mediated by GPR55.

Given the vast therapeutic potential of the endocannabinoid system, the revelation of a novel cannabinoid-sensitive target was treated with great excitement. The orphan G-protein coupled receptor 55 (GPR55) was initially touted as a novel cannabinoid target in early industrial patent literature. Consequently, numerous studies have revealed GPR55 expression in a diverse array of cells and tissue...