منابع مشابه
Oestrogen and androgen receptors
of the impacted safety pin had clearly ceased. Also the pin had caused epigastric pain and a small haemorrhage, and required removal. In view of the previous abnormalities in the right upper abdomen and the patients' cardiac status, laparotomy and duodenotomy would have been technically difficult and of considerable risk to the patient. Fibre-optic endoscopy has found a number of diagnostic and...
متن کاملNuclear receptors in disease: the oestrogen receptors.
For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects. The ERs belong to the family of ligand-activated nuclear receptors, which act by modulating the expression of target genes. Studies of ER-knock...
متن کاملOestrogen receptors in colorectal carcinoma.
The oestrogen receptor content of colorectal adenocarcinoma was investigated using an established ligand binding biochemical assay and two more recently introduced techniques using specific monoclonal antibodies (Abbott ER-EIA and ER-ICA assay kits). Twenty nine tumours were investigated by the ligand binding assay. Only one (3.4%) tumour gave a weakly positive result (11 fmol/mg cytosol protei...
متن کاملOestrogen action on bone cells.
Sex steroids have an important impact on bone physiology. Oestrogen (E) appears to be the most important sex steroid in preventing osteoporosis in women. Despite the overwhelming evidence that oestrogens modulate bone growth and turnover in vivo, oestrogen receptors (ER) were detected only recently. Two forms of ER have been discovered so far, ERalpha and ERbeta. Both have been detected in oste...
متن کاملOestrogens and oestrogen receptors in prostate cancer
The role of androgens in prostate cancer is obvious due to the fact that androgen signalling is the main regulator of prostate growth and function. Androgen deprivation therapy is a mainstay treatment for advanced prostate cancer. However, prostate cancer often becomes androgen-independent, which in consequence leads to lethal and incurable disease. In addition, oestrogens play a crucial role i...
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ژورنال
عنوان ژورنال: Acta Paediatrica
سال: 2007
ISSN: 0803-5253,1651-2227
DOI: 10.1111/j.1651-2227.2007.00415.x