Odontoblast-targeted Bcl-2 overexpression promotes dentine damage repair
نویسندگان
چکیده
منابع مشابه
TRANSLATIONAL PHYSIOLOGY Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss
Wang, Liming, Shiguang Liu, L. Darryl Quarles, and Robert F. Spurney. Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. Am J Physiol Endocrinol Metab 288: E826–E834, 2005. First published December 7, 2004; doi:10.1152/ajpendo.00422.2004.—To investigate the role of G protein-coupled receptor kinases (GRKs) in regulating bone formation in vivo, we o...
متن کاملTargeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.
To investigate the role of G protein-coupled receptor kinases (GRKs) in regulating bone formation in vivo, we overexpressed the potent G protein-coupled receptor (GPCR) regulator GRK2 in osteoblasts, using the osteocalcin gene-2 promoter to target expression to osteoblastic cells. Using the parathyroid hormone (PTH) receptor as a model system, we found that overexpression of GRK2 in osteoblasts...
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Overexpression of the antiapoptotic Bcl-2 protein enhances the uptake of fluorimetric dyes sensitive to mitochondrial membrane potential, suggesting that Bcl-2 changes the mitochondrial proton gradient. In this study, we performed calibrated measurements of mitochondrial respiration, membrane potential, deltapH, and intramitochondrial [K+] in digitonin-permeabilized PC12 and GT1-7 neural cells ...
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Although immunotherapy based on the adoptive transfer of tumor-specific T lymphocytes has been shown to result in dramatic clinical responses in some patients, the relatively low levels of engraftment and persistence of the adoptively transferred cells may limit these responses in many patients. In an attempt to develop strategies for prolonging the survival of adoptively transferred T cells, w...
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Dynamic protein-protein interactions between proapoptotic and pro-survival Bcl-2 family members regulate outer-mitochondrial membrane permeabilization and cytochrome c release, key events in the path to apoptosis. Their relative levels often dictate the fate of a cell following an apoptotic stimulus. However, in cancer cells, the pro-survival Bcl-2 family members are frequently upregulated, the...
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ژورنال
عنوان ژورنال: Archives of Oral Biology
سال: 2012
ISSN: 0003-9969
DOI: 10.1016/j.archoralbio.2011.08.022