Ocular Delivery of Atenolol Loaded Microsponge in-situ Gel: Development, Characterization and in-vitro Evaluation

Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery

Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC)  ratios were prepared and their stability was tested in P...

Formulation and In-Vitro Evaluation of Fluconazole Loaded Microsponge Gel For Topical Sustained Delivery

The objective of present work was to formulate and evaluate Fluconazole (FLZ) microsponges using quasi emulsion solvent diffusion technique and microsponge gel by using carbopol. Microsponges containing FLZ were obtained successfully with different proportions of ethyl cellulose polymer (EC). The formulations were studied for particle size and physical characterization. The physical characteriz...

Exploring the potential of complex-vesicle based niosomal ocular system loaded with azithromycin: Development of in situ gel and ex vivo characterization

Abstract Bacterial conjunctivitis characterized as pink eye referred as an inflammation of an eye caused by the enlargement of blood vessels present in conjunctiva, resulting in a red or bloodshot appearance of the eyes. Topical ocular delivery is found to be useful in treating conjunctivitis, but to maintain an effective drug concentration at a site of action in order to achieve desired pha...

Development and Evaluation of Carbamazepine Loaded Transfersomal In-situ Gel for Nose to Brain Delivery

The microsponge delivery system of Acyclovir: Preparation, characterization and in-vitro evaluation

The aim of the present study was to develop and evaluate microsponge based topical delivery system of acyclovir for sustained and enhanced drug deposition in the skin. Microsponges containing acyclovir were prepared by an emulsion solvent diffusion method. The effect of formulation variable such as drug: polymer ratio, stirring speed, internal phase on the physical characteristics of microspong...