Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery
نویسندگان
چکیده
منابع مشابه
[Development of a novel artificial gene delivery system multifunctional envelope-type nano device for gene therapy].
For efficient gene delivery to the nucleus, nonviral vectors need to overcome several barriers such as the plasma membrane, endosomal membrane, and nuclear membrane. To overcome these obstacles, it is necessary to equip the delivery system with various functional devices. However, it is difficult to package all such functional devices into a single system to exert each of their functions at the...
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This review introduces a new concept "Programmed Packaging" to develop a non-viral gene delivery system. Based on this concept, multifunctional envelope type nano devices (MEND) were developed for in vitro, in situ and in vivo conditions. A quantitative study to identify a rate limiting step in intracellular trafficking was also shown between viral and non-viral vectors, which indicated an impo...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2007
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3302910