Observations on the oxidation of homogentisic acid in urine
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چکیده
منابع مشابه
Observations on the oxidation of homogentisic acid in urine.
Homogentisic acid, which is considered to be an intermediate in the metabolism of tyrosine and phenylalanine, is excreted in a number of different conditions. The most widely studied of these, which is caused by a genetic inability to oxidize homogentisic acid, was termed alcaptonuria, owing to the characteristic darkening of the urine on standing. It has also been shown (Sealock & Silberstein,...
متن کاملDetermination of homogentisic acid in urine.
A relatively simple method for the quantitative determination of homogentisic acid in urine is presented. Homogentisic acid (2,5-dihydroxyphenylacetic acid) is oxidized by atmospheric oxygen in mild alkali to form 1,4-benzoquinone-2-acetic acid. The latter compound is then conjugated with 2,4-dinitrophenylhydrazine. The resulting hydrazone, in the presence of alcoholic sodium hydroxide, produce...
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The biochemical study of homogentisic acid may be said to have begun with the work of Wolkow and Baumann (3), who demonstrated the relation of this compound to the metabolism of tyrosine. The intervening years have seen much effort expended on studies of the pathway of formation of homogentisic acid, but little on its further metabolism beyond the early discovery that it gives rise to ketone bo...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1951
ISSN: 0306-3283
DOI: 10.1042/bj0500274