OBSERVATIONS ON BLOOD ACETOL AFTER ADMINISTRATION OF ACETOL, METHYL ALCOHOL, AND FORMALDEHYDE TO RABBITS
نویسندگان
چکیده
منابع مشابه
The enzymatic oxidation of 1,2-propanediol phosphate to acetol phosphate.
Lindberg (I) has presented evidence for the occurrence of 1,2propanediol phosphate in beef brain. This compound has also been reported to occur in other tissues (2-4). However, the structure, metabolism, and biological significance of this compound is unknown. Groth et al. (5) have reported that (Y-labeled pyruvate is incorporated into propanediol-P’ under anaerobic conditions in fluoride-inhib...
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Pharmaceutical excipients for topical use may contain impurities, which are often neglected from a toxicity qualification viewpoint. The possible impurities in the most frequently used topical excipients were evaluated in-silico for their toxicity hazard. Acetol, an impurity likely present in different topical pharmaceutical excipients such as propylene glycol and glycerol, was withheld for the...
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Escherichia coli Lin43 is a strain which has some mutations in glycerol kinase (GlpK) and the repressor for the glycerol 3-phosphate regulon (GlpR). When exposed to glycerol, it quickly accumulates lethal levels of methylglyoxal, which is a precursor of acetol; acetol is important for the manufacture of polyols, acrolein, dyes, and skin tanning agents. This work reports the engineering of E. co...
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The vapour phase selective conversion of glycerol to acetol at normal atmospheric pressure in a fixed-bed micro reactor was investigated over SO4 2 and WOx promoted ZrO2 and M-ZrO2 (M = Al2O3 or TiO2) solid acid catalysts. The investigated sulfate and tungstate ion promoted zirconia-based catalysts were prepared by both coprecipitation and impregnation methods and calcined at 923 K. The synthes...
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hisH encodes imidazole acetol phosphate (IAP) aminotransferase in Zymomonas mobilis and is located immediately upstream of tyrC, a gene which codes for cyclohexadienyl dehydrogenase. A plasmid containing hisH was able to complement an Escherichia coli histidine auxotroph which lacked the homologous aminotransferase. DNA sequencing of hisH revealed an open reading frame of 1,110 bp, encoding a p...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1948
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)57378-6