Objectives and Methods of Iron Chelation Therapy
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چکیده
منابع مشابه
Objectives and Methods of Iron Chelation Therapy
Recent developments in the understanding of the molecular control of iron homeostasis provided novel insights into the mechanisms responsible for normal iron balance. However in chronic anemias associated with iron overload, such mechanisms are no longer sufficient to offer protection from iron toxicity, and iron chelating therapy is the only method available for preventing early death caused m...
متن کاملTransfusion Iron Chelation Therapy
As a unique electron donor and acceptor, iron is an essential element in most biological systems. However, its chemical reactivity can result in iron potentially becoming a toxin when present in excessive quantities; accordingly, total body iron must be tightly regulated. As humans have no physiological mechanism for the elimination of excess iron, body iron is controlled mainly by the degree o...
متن کاملIron-chelation therapy: an update.
Chronically transfused patients develop iron overload that leads to organ damage and ultimately to death. The introduction of the iron-chelating agent, desferrioxamine mesylate, dramatically improved the life expectancy of these patients. However, the very demanding nature of this treatment (subcutaneous continuous infusion via a battery-operated portable pump) has been the motivation for attem...
متن کاملPerspectives Objectives of iron chelation therapy in myelodysplastic syndromes: more than meets the eye?
The role of iron chelation therapy in myelodysplastic syndrome (MDS) remains controversial. Averting cardiac dysfunction in low-grade MDS patients who have sufficient longevity to experience deleterious cardiac effects of iron overload has been the major argument in favor of iron chelation. Although there is significant evidence showing the adverse impact of transfusion dependency on survival i...
متن کاملObjectives of iron chelation therapy in myelodysplastic syndromes: more than meets the eye?
The role of iron chelation therapy in myelodysplastic syndrome (MDS) remains controversial. Averting cardiac dysfunction in low-grade MDS patients who have sufficient longevity to experience deleterious cardiac effects of iron overload has been the major argument in favor of iron chelation. Although there is significant evidence showing the adverse impact of transfusion dependency on survival i...
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ژورنال
عنوان ژورنال: Bioinorganic Chemistry and Applications
سال: 2003
ISSN: 1565-3633
DOI: 10.1155/s1565363303000128