Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness

Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness

Memory and mood deficits are the enduring brain-related symptoms in Gulf War illness (GWI). Both animal model and epidemiological investigations have indicated that these impairments in a majority of GW veterans are linked to exposures to chemicals such as pyridostigmine bromide (PB, an antinerve gas drug), permethrin (PM, an insecticide) and DEET (a mosquito repellant) encountered during the P...

Examining object location and object recognition memory in mice.

This unit is designed to provide sufficient instruction for the setup and execution of tests for object location and object recognition in adult mice. This task is ideally suited for the study of a variety of mouse models that examine disease mechanisms and novel therapeutic targets. By altering several key parameters, the experimenter can investigate short-term or long-term memory and look for...

Effects of forced exercise on object location memory and anxiety behaviour in morphine dependent ovariectomized rats

Introduction: Previous findings from our laboratory indicated that exercise alleviates the deficits in cognitive and anxiety disorders in healthy female rats. But the effect of exercise on cognitive and anxiety disorders induced by chronic morphine in experimental monopose of rats (ovariectomized) not known. Aim of this study was to investigate the effects of mild and modorate forced exercise o...

The protective effect of hesperetin and nano-hesperetin on object recognition memory in animal model of Alzheimer

Background and objectives: Hesperetin (Hst), aglycone form of hesperidin, is reported to have antioxidant, anti-inflammatory and neuroprotective activities. On the other hand, the latest nanoparticle technology can help to improve the bioavailability of Hst, which is affected by the final particle size and stability. Alzheimer’s disease is a neurodegenerative disease, character...

Therapeutic Approaches for the Treatment of Depression and Cognitive Deficits in a Rodent Model of Gulf War Veterans’ Illness