Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age

Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans.

Leptin is an adipocyte-secreted hormone important in energy homeostasis and diverse physiological processes. A circulating soluble form of the leptin receptor [soluble leptin receptor (sOB-R)] is the main leptin-binding protein and determinant of free leptin index (FLI), the presumed biologically active form of leptin. We performed observational and interventional studies to elucidate the regul...

Soluble leptin receptor levels in patients with chronic renal failure.

Soluble leptin receptor (SLR) is the extracellular part of the leptin receptor. This protein is released into circulation and constitutes the main circulating leptin-binding protein. The aim of our study was to measure SLR concentrations in patients with chronic renal failure (CRF) and healthy subjects and to explore the relationship of SLR to other hormones and cytokines. The patients with CRF...

association of serum soluble leptin receptor and leptin levels with breast cancer

background: leptin plays a key role in the regulation of energy expenditure and is known to circulate in both free and bound forms. soluble leptin receptor (sob-r) is a unique circulating form of leptin receptor that can bind to leptin. leptin and leptin receptor have been implicated in processes leading to breast cancer initiation and progression. our study was aimed to investigate the relatio...

Correlation of leptin and soluble leptin receptor levels with anthropometric parameters in mother-newborn pairs.

The aim of this study was to investigate if anthropometric parameters are associated with both leptin and soluble leptin receptor (sLEPR) levels in newborns and their mothers. This cross-sectional study was performed in 118 mother-newborn pairs. The venous blood sample of mothers was taken before delivery and immediately after delivery an umbilical cord blood sample was collected. Levels of lep...