Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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چکیده
منابع مشابه
Cyclin - dependent kinase 5 modulates STAT 3 and androgen receptor activation 1 through phosphorylation of Ser 727 on STAT 3 in prostate cancer cells
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Polypeptide growth factors and cytokines elicit their effects by activating specific cell-surface receptors, thereby initiating signaling cascades that culminate in the induction of specific subsets of genes. Initially identified as the primary mediators of interferon-dependent signaling, JAKs and STATs are now known to be utilized by many different extracellular signaling proteins. In this rep...
متن کاملActivated stat-3 in melanoma.
BACKGROUND Recent studies have demonstrated that the Src-Stat pathway may play an important role in melanoma. We examined the expression of phosphorylated Stat-3 (pStat-3), activated Stat-1 (pStat-1) and interferon alpha receptor subunit 1(IFNAR-1) in human melanocytic neoplasms. METHODS Compound nevi (6), dysplastic nevi (4), congenital nevi (2), primary melanoma (14), and sentinel lymph nod...
متن کاملStat 6341 , Statistical Computing Stat 6341 Syllabus STAT 6341
Instructor: Dr. Larry P. Ammann Office hours: MW 2:30-3:30pm, others by appt. Email: [email protected] Office: FO 2.410C Phone: (972) 883-2161 Text: Modern Applied Statistics with S, 4 Ed. Authors: W.N. Venables and B.D. Ripley Additional resources: Matrix Computations Authors: G. Golub and C. van Loan These notes are copyrighted by their author, Larry P. Ammann, and are intended for the use ...
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ژورنال
عنوان ژورنال: Cell
سال: 2018
ISSN: 0092-8674
DOI: 10.1016/j.cell.2018.09.053