Obesity does not negatively influence cartilage repair or cause osteoarthritis in DBA/1 mice
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چکیده
منابع مشابه
Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis
INTRODUCTION Cathepsin K (catK) expression is increased in cartilage, bone and synovium during osteoarthritis (OA). To study the role of catK expression and elevated cathepsin activity in the synovium on cartilage destruction in established OA, we overexpressed cystatin C (cysC), a natural cysteine protease inhibitor, in the synovium of rabbit OA joints. METHODS The ability of cysC to inhibit...
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It is well known that the capacity for repair of articular cartilage is limited. Hunter in 1743, stated that: " from Hippocrates to the present age, it is universally allowed that ulcerated cartilage is a troublesome thing and that when destroyed, it is not recovered ". 1 There has been complacent acceptance of the common and random degeneration of joints with ageing. 2,3 Notions that degenerat...
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Objective: Female metabolism is highly responding towards diet associated changes. Monosodium glutamate is a popular flavor enhancer, which is widely used to develop umami taste. Young female generation nowadays deals with more issues related to metabolism and fertility. Present study is an effort to monitor the effect of monosodium glutamate oral consumption on female mice health and obesity. ...
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BACKGROUND The aim of this study was to examine whether cartilage volume as measured by MRI and radiographic osteoarthritis (OA) at baseline predict cartilage volume loss over ten years independent of each other and other structural co-pathologies. METHODS 219 participants [mean-age 45(26-61); 57 % female] were studied at baseline and ten years. Approximately half were the adult offspring of ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2015
ISSN: 1063-4584
DOI: 10.1016/j.joca.2015.02.882