منابع مشابه
Impaired Muscle Regeneration in Ob/ob and Db/db Mice
In obesity and type 2 diabetes, efficient skeletal muscle repair following injury may be required, not only for restoring muscle structure and function, but also for maintaining exercise capacity and insulin sensitivity. The hypothesis of this study was that muscle regeneration would be impaired in ob/ob and db/db mice, which are common mouse models of obesity and type 2 diabetes. Muscle injury...
متن کاملWnt10b inhibits obesity in ob/ob and agouti mice.
The Wnt family of secreted signaling molecules has profound effects on diverse developmental processes, including the fate of mesenchymal progenitors. While activation of Wnt signaling blocks adipogenesis, inhibition of endogenous Wnt/beta-catenin signaling by Wnt10b promotes spontaneous preadipocyte differentiation. Transgenic mice with expression of Wnt10b from the FABP4 promoter (FABP4-Wnt10...
متن کاملHypothalamic neuronal activity and intermediary metabolism in ob/ob mice
Introduction: Obesity is a pandemic syndrome, associated with the most prevalent and mortal pathologies in developed countries (Rajala and Scherer, 2003). This pathology results from an imbalance in the control of food intake and energy homeostasis as regulated by a complex network of peripheral and intra-hypothalamic signalling systems (Schwartz et al., 2000). On this basis, the investigation ...
متن کاملGlucocerebroside ameliorates the metabolic syndrome in OB/OB mice.
Glucocerebroside (GC) is a naturally occurring glycolipid that may alter natural killer T (NKT) cell function. To determine the effect of GC on the metabolic derangements and immune profile in leptin-deficient mice, Ob/Ob mice were treated by daily injections of GC for 8 weeks and followed for various metabolic and immunological parameters. Marked amelioration of the metabolic alterations chara...
متن کاملCorrection: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice
[This corrects the article DOI: 10.1371/journal.pone.0160431.].
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ژورنال
عنوان ژورنال: Musicological Annual
سال: 2015
ISSN: 2350-4242,0580-373X
DOI: 10.4312/mz.51.1.7-8