O4A.1 Night shiftwork, dna methylation, and telomere length in female nurses
نویسندگان
چکیده
منابع مشابه
Leukocyte telomere length, T cell composition and DNA methylation age
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanM...
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Background and Aim: One of the major challenges in the health sector, especially in relation to nurses, is shiftwork that can have many negative consequences for this group. Therefore, the purpose of this study was to comparison of marital satisfaction, intimacy and sexual function in female married nurses with fixed and changing shiftwork in Abadan city government hospitals. Methods: The rese...
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TRF2, a component of the shelterin complex, functions to protect telomeres. TRF2 contains an N-terminal basic domain rich in glycines and arginines, similar to the GAR motif that is methylated by protein arginine methyltransferases. However, whether arginine methylation regulates TRF2 function has not been determined. Here we report that amino acid substitutions of arginines with lysines in the...
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In the present study, the authors investigated the effects of shiftwork exposure on DNA methylation using peripheral blood DNA from subjects working in two chemical plants in Northern Italy. The investigation was designed to evaluate (a) DNA methylation changes in Alu and long interspersed nuclear element-1 (LINE-1) repetitive elements as a surrogate of global methylation and (b) promoter methy...
متن کاملAssociation between Genetic Variants in DNA and Histone Methylation and Telomere Length
Telomere length, a biomarker of aging and age-related diseases, exhibits wide variation between individuals. Common genetic variation may explain some of the individual differences in telomere length. To date, however, only a few genetic variants have been identified in the previous genome-wide association studies. As emerging data suggest epigenetic regulation of telomere length, we investigat...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 2019
ISSN: 1351-0711,1470-7926
DOI: 10.1136/oem-2019-epi.85