O43: CLINICAL IMPACT OF GENE FUSIONS IN BREAST CANCER BRAIN METASTASES
نویسندگان
چکیده
Abstract Introduction The incidence of brain metastases is increasing despite longer survival rates for patients with advanced breast cancer. identification novel therapeutic targets these an urgent unmet clinical need. Sequencing metastatic tumours have largely focused on mutations however gene fusions important, yet underappreciated role in tumorigenesis and disease progression. In this study, we investigate the their impact altered responses. Method RNA sequencing was performed largest reported cohort patient matched primary resected (45 n=90 samples). Expressed were detected computationally using STAR-Fusion Arriba. Result We identified differential fusion burden (medium 58) vs. 38) (p < 0.05). Enrichment pathways associated tumour cell plasticity proliferation recurrent known cancer driver genes related to MAPK, HER signaling identified. Of note, a CDK12 importance. Increased genomic alterations over expression free independent recorded history metastases. It has been proposed that inhibition may induce BRCAness making them sensitive PARP inhibition. Conclusion These results highlight significant Abbreviations MAPK Mitogen Activated Protein Kinase, Human Epidermal Receptor, Cyclin Dependent Kinase 12 Take-home message offer specific actionable be exploited.
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2021
ISSN: ['1365-2168', '0007-1323']
DOI: https://doi.org/10.1093/bjs/znab117.043