O-267 Uterine contractility in women with adenomyosis differs significantly from healthy control women - the waves study

Abstract Study question Description of uterine contractility characteristics in adenomyosis patients compared to healthy controls and according degree dysmenorrhoea measured by quantitative 2D transvaginal ultrasound (TVUS). Summary answer Women with show differences contraction patterns (frequency, amplitude, velocity, coordination) depending on dysmenorrhoea. What is known already The natural pattern the uterus changes throughout menstrual cycle response cyclic hormones. In abnormal uteri, such as adenomyotic this may be different. Adenomyosis can cause dysmenorrhoea, menorrhagia, dyspareunia, subfertility. These symptoms could explained different uterus, however, has not yet been objectively quantified due absence a suitable measurement tool. Recently, speckle-tracking strain analysis TVUS was used assess coordination, frequency, direction, phase women. design, size, duration This study part an ongoing multi-centre prospective observational cohort investigating recordings. Our includes recordings 31 women 106 uteri. Patients were included 3 centres from 2017 2023 (Netherlands, Greece, Italy). Participants/materials, setting, methods sonographic suspicion uteri cycles included. Uterine coordination assessed applying dedicated speckle tracking 2-4-minute midsagittal section. Degree visual analogue score (VAS). their cycle. Main results role chance Age, BMI, parity volume significantly higher (p < 0.05). differed between during periovulatory phase, revealing lower frequency (1.50±0.25 vs. 1.75±0.35, p = 0.031), amplitude (0.076±0.039 0.046±0.018, 0.001), velocity (0.64±0.18 0.84±0.22, 0.020) contractions group patients. late luteal showed (0.050±0.02 0.035±0.01, 0.039) (0.51±0.11 0.72±0.16, 0.032) than controls. During menstruation, trend towards (0.044± 0.01 0.037±0.01, 0.051) menstrual, reduced 0.047, 0.015 0.011, respectively) Increased (VAS score) overall associated 0.043) tendency 0.160) 0.154). Limitations, reasons for caution No sub-analysis done effects additional (i.e. severity, type, location). extensive impossibility perform images. older, had BMI larger volumes Wider implications findings differs versus More also pattern. suggests aetiological mechanism clinical presentation subfertility) presents potential therapeutic markers. Trial registration number NL52466.100.15