O-138 Factors influencing sperm retrieval rate of microdissection testicular sperm extraction in nonobstructive azoospermia patients with different etiologies: a retrospective study of 3104 patients

Abstract Study question What are predictors of successful sperm retrieval (SRR) with microdissection testicular extraction (mTESE) in men non-obstructive azoospermia (NOA) according to different etiologies? Summary answer Predictors for SRR were patients various etiologies and effects age on idiopathic NOA KS opposite. is known already due spermatogenic dysfunction, accounting about 60 percent the total cases, may have opportunities obtain by mTESE overall 50%. There some predictive factors at including age, testis volume, serum follicle stimulating hormone (FSH), testosterone (T), inhibin B, anti-Mullerian histopathology, while remains underappreciated, especially accordance type etiology. Most notably, there controversies relationship between SSR surgery. design, size, duration This retrospective study involved 3104 treated first Reproductive Medical Centre Peking University Third Hospital from March 2012 December 2022. Participants/materials, setting, methods classified into seven groups 1530 males (iNOA), 763 Klinefelter syndrome (KS), 345 microdeletion AZFc, 177 cases history cryptorchidism, 131 a mumps orchitis, 89 cryptozoospermia 69 other causes. The end-point was presence one or more sperm. Multi-variable logistic regression used analyze outcome. Main results role chance Overall 43.46%, highest 89.31% orchitis lowest 29.35% iNOA patients. For negative T (0.805 [0.654, 0.991] p = 0.041). patients, shorter infertility (0.837 [0.704, 0.995], 0.044). Males bigger testes had likelihood positive (1.077 [1.005; 1.153], 0.035) cryptorchidism. BMI an independent factor AZFc-deleted (1.084 [1.013, 1.161], 0.020). lower male (0.938 [0.898, 0.979], 0.004) (1.214[1.099, 1.342], p＜0.001) SRR. Lower levels FSH (0.984[0.970, 0.998] 0.025) higher age(1.079[1.050, 1.110], So, optimum range undergoing should be 30 35 years old 29.13% when considering low aged＜30 (23.96%) effect female ICSI Limitations, reasons caution Surgeon performing maybe another predictor which potential selection bias. Inhibin B Anti-Müllerian weren’t included limited information our database. We couldn’t verify conclusion population multicenter despite current large sample size so far. Wider implications findings Our provide valuable who want counsel surgeons their treatments help perform shared decision-making optimal therapy methods, Trial registration number not applicable