O-081 A 10-year follow-up of reproductive outcomes in women returning after elective oocyte cryopreservation

Abstract Study question What are the reproductive treatment outcomes in women who underwent elective oocyte cryopreservation (EOC) returning to our clinic with a desire for child? Summary answer Whether warm oocytes or first use fresh ART depends on age upon returning, but both strategies resulted favourable outcomes. is known already Most affluent countries have observed trend towards postponement of childbearing, and EOC increasingly used an attempt extend lifespan mitigate age-related fertility decline. Although most follow-up studies after focused requested warming, substantial proportion do not conceive naturally eventually embark without using their cryopreserved oocytes. Reports past users scarce, lack algorithms this group hampers efficiency clinical practice. design, size, duration This retrospective observational single-center study includes 843 had vitrification non-medical reasons between 2009 2019, describes diverse that were performed these when they returned same because pregnancy until May 2022. Participants/materials, setting, methods Patient characteristics data ovarian stimulation cycles analyzed, as well related laboratory pursued and/or The primary outcome was live birth rate (LBR) per patient warming Secondary LBR embryo transfer. Main results role chance A total 1353 (1.6 ± 0.9 patient) performed. Mean 36.5 2.8 years. At time 174 (20,6%) partner. On average, 13.7 9.2 mature cryopreserved. After 39.9 23.4 months, 231 (27.4%) clinic. Upon mean 40.4 3.1 years, AMH 2.3 2.0 ng/mL, 150/231 (64,9%) patients As approach, 110/231 (47.6 %) embarked 50/231 (21.6%) intrauterine insemination, 71/231 (30.7%) Cumulative (CLBR) 45.9 % (106/231) miscarriage (MR) 30.7% (51/166) entire cohort. subset 90/231 (39.0%) exclusively at 41.6 3.0 10.0 5.2 warmed patient. 52/231 (22.5%) oocytes, 39.0 9.9 7.4 retrieved CLBR 37/90 (41.1%) warming-only 25/52 (48.1%) OS-only group. MR/transfer 25.0% 29.3% group, respectively. Limitations, caution Both small sample size design limitations study. decision specific strategy based preference, counseling options. precludes direct comparison efficacy options users. Wider implications findings Reporting divergent mandatory establish guidelines best practice growing population. Trial registration number Not applicable