Nutritional regulation of IGF-II, but not IGF-I, is age dependent in sheep
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چکیده
منابع مشابه
Amniotic IGF-I supplements improve gut growth but reduce circulating IGF-I in growth-restricted fetal sheep.
Insulin-like growth factor I (IGF-I) is an important regulator of fetal growth, and circulating concentrations are reduced in intrauterine growth-restricted (IUGR) fetuses. We investigated whether IGF-I administered into amniotic fluid could ameliorate IUGR in fetal sheep. Fetuses were assigned to control (n = 9), IUGR+saline (n = 12), or IUGR+IGF-I groups (daily intra-amniotic IGF-I injections...
متن کاملLiver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice.
The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have abolished IGF-I production in the livers of mice by using the Cre/loxP recombination system. These mice demonstrated complete inactivation of the...
متن کاملIGF-I regulates the age-dependent signaling peptide humanin
Aging is influenced by endocrine pathways including the growth hormone/insulin-like growth factor-1 (GH/IGF) axis. Mitochondrial function has also been linked to the aging process, but the relevant mitochondrial signals mediating the effects of mitochondria are poorly understood. Humanin is a novel signaling peptide that acts as a potent regulator of cellular stress responses and protects from ...
متن کاملComments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF is a major physiological regulator, but not solely responsible for muscle mass regulation.
TO THE EDITOR: This is a timely Point:Counterpoint that addresses the role of IGF-I in the regulation of muscle mass. Clearly, IGF-I is critical for muscle development and postnatal muscle growth (2). However, its role in the area of loadinduced muscle hypertrophy has been recently questioned (5). There are a few clarifications that should be made, in that the mice used in my study are not knoc...
متن کاملAssociation of IGF-I Gene Polymorphisms with Carcass Traits in Iranian Mehraban Sheep Using SSCP Analysis
Molecular genetics selection on individual genes is a promising method to genetically improve economically important traits in livestock. The insulin like growth factor-I (IGF-I) gene may play important roles in growth of multiple tissues, including muscle cells, cartilage and bone. The objectives of the present study were the estimate the haplotype frequencies of the IGF-I gene polymorphisms i...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 1999
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1630395