Nutritional regulation of glucagon-like peptide-1 secretion
نویسندگان
چکیده
منابع مشابه
Neural regulation of glucagon-like peptide-1 secretion in pigs.
Glucagon-like peptide (GLP)-1 is secreted rapidly from the intestine postprandially. We therefore investigated its possible neural regulation. With the use of isolated perfused porcine ileum, GLP-1 secretion was measured in response to electrical stimulation of the mixed, perivascular nerve supply and infusions of neuroactive agents alone and in combination with different blocking agents. Elect...
متن کاملDirect and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2.
The proglucagon-derived peptide family consists of three highly related peptides, glucagon and the glucagon-like peptides GLP-1 and GLP-2. Although the biological activity of glucagon as a counter-regulatory hormone has been known for almost a century, studies conducted over the past decade have now also elucidated important roles for GLP-1 as an antidiabetic hormone, and for GLP-2 as a stimula...
متن کاملNutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
BACKGROUND The positive influences of glucagon-like peptide-1 (GLP-1) on blood glucose homeostasis, appetite sensations, and food intake provide a strong rationale for its therapeutic potential in the nutritional management of obesity and type 2 diabetes. AIM To summarize GLP-1 physiology and the nutritional modulation of its secretion in the context of obesity and type 2 diabetes management....
متن کاملGlucagon-Like Peptide-1
Ma Glucagon-like peptide-1-(7-36) amide (GLP-1) is a human incretin hormone responsible for the release of insulin in response to food. Pre-clinical and human physiological studies have demonstrated cardioprotection from ischemia-reperfusion injury. It can reduce infarct size, ischemic left ventricular dysfunction, and myocardial stunning. GLP-1 receptor agonists have also been shown to reduce ...
متن کاملGLUCAGON-LIKE PEPTIDE 1: BIOChEMISTRy, SECRETION AND MAIN PhySIOLOGICAL EFFECTS
the peptide hormone glucagon-like peptide 1 (glp-1), produced in the intestinal l-cells by differential processing of proglucagon, is secreted in response to meal intake. glp-1 affects various systems, the gastrointestinal and pancreatic systems being the best studied, either by direct binding to the glp-1 receptor, at the target-cells surface, or indirectly as a result of paracrine regulation....
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2009
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2008.164012