Nutrients and Pathways that Regulate Health Span and Life Span
نویسندگان
چکیده
منابع مشابه
Life Span and Disability
Psychiatric functioning and disability have historically been considered separate from the broader disability field and have been measured differently than other medical conditions. This paper provides an overview of the current concepts and international advances in the classification of psychiatric disability and explores the controversies and goals within the proposed systems. It highlights ...
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We review three approaches to the genetic analysis of the biology and pathobiology of human aging. The first and so far the best-developed is the search for the biochemical genetic basis of varying susceptibilities to major geriatric disorders. These include a range of progeroid syndromes. Collectively, they tell us much about the genetics of health span. Given that the major risk factor for vi...
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Humans age at different rates and families with exceptional survival provide the opportunity to understand why some people age slower than others. Unique features exhibited by centenarians include a family history of longevity, compression of morbidity with resultant extension of health span, and biomarkers such as low-circulating insulin-like growth factor 1 (IGF-1) and elevated high-density l...
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OBJECTIVES Population ageing and the increasing burden of chronic conditions challenge traditional metrics of assessing the efficacy of health care interventions and as a consequence policy and planning. Using chronic heart failure (CHF) as an exemplar this manuscript seeks to describe the importance of patient-reported outcomes to inform policy decisions. METHODS The method of an integrative...
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As a tool for measuring the aging process, life span has been invaluable in dissecting the genes that modulate longevity. Studies over the past few decades have identified several hundred genes that can modify life span in model organisms such as yeast, worms, and flies. Yet, despite this vast amount of research, we still do not fully understand how the genes that affect life span influence how...
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ژورنال
عنوان ژورنال: Geriatrics
سال: 2020
ISSN: 2308-3417
DOI: 10.3390/geriatrics5040095