Nupr1 mediates renal fibrosis via activating fibroblast and promoting epithelial?mesenchymal transition

Renal fibrosis and the origin of the renal fibroblast.

Many studies have determined that the extent of tubulointerstitial involvement, particularly fibrosis, correlates better with renal function than glomerular changes do, thus, the extent of tubulointerstitial damage in any given renal biopsy has important implications for the renal prognosis of the patient (summarized in [1]). Tubulointerstitial fibrosis is characterized by the accumulation of e...

Cancer-Associated-Fibroblast Induces Epithelial-Mesenchymal Transition of Gastric Cancer Cells via Activating Thy-1

1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , P. R. China 2Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China 3Cancer Research Group, The Canberra Hospital, and ANU Medical School, The Australia National University, Garran , ACT, Australia 4Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong ...

D-Pinitol alleviates cyclosporine A-induced renal tubulointerstitial fibrosis via activating Sirt1 and Nrf2 antioxidant pathways

Although the mechanism of cyclosporine A (CsA)‑induced renal injury remains to be fully elucidated, accumulating evidence suggests that oxidative stress is critical in producing CsA‑induced structural and functional renal impairment. The present study investigated the effect of D‑pinitol, a cyclitol present in soybean, on chronic CsA nephropathy. Male ICR mice were treated with vehicle, CsA (30...

PAI1 mediates fibroblast-mast cell interactions in skin fibrosis.

Fibrosis is a prevalent pathological condition arising from the chronic activation of fibroblasts. This activation results from the extensive intercellular crosstalk mediated by both soluble factors and direct cell-cell connections. Prominent among these are the interactions of fibroblasts with immune cells, in which the fibroblast-mast cell connection, although acknowledged, is relatively unex...

klotho and renal fibrosis