Numerical simulation of the viral entry into a cell driven by receptor diffusion

The present study focuses on the receptor driven endocytosis typical of viral entry into a cell. A locally increased density receptors at time contact between cell and virus is necessary in this case. considered as substrate with fixed its surface, whereas host are free to move over membrane, allowing local change their concentration. In zone membrane inflects forms an envelope around virus. created vesicle imports cargo This paper assumes diffusion equation accompanied by boundary conditions requiring conservation binders describe process. Moreover, it introduces condition defining energy balance front adhesion zone. latter yields upper limit for size which can be engulfed membrane. described moving problem terms binder velocity well posed numerically solved using finite difference method. illustrative examples have been chosen show influence process parameters initiation duration