Numerical modeling of experimental human fibrous cap delamination

Optical Coherence Tomography and Fibrous Cap Characterization

The pathophysiology of acute coronary syndromes has long been associated with atherosclerotic plaque rupture. Inflammation, thinning, and disruption of the fibrous cap have been implicated with the final processes leading to plaque rupture, but confirmation of these mechanisms of coronary thrombosis in humans has been hampered by the lack of imaging methods with sufficient resolution to resolve...

Numerical Determination of Delamination Onset in Laminated Symmetric DCB Specimen

In this study, a novel numerical method is proposed for determination of mode-I interlaminar fracture toughness, GIc, in multi-directional (MD) double cantilever beam (DCB) specimens using fracture properties of unidirectional DCB specimens. Two factors, β and Dc are defined to minimize the undesirable effects on strain energy release rate. β describes the difference between maximum and average...

Delamination Behaviour of 3d-textile Reinforced Composites – Experimental and Numerical Approaches

The requirements on aircraft engine design have increased rapidly over the last decades. Future aircrafts engines are expected to be more efficient with lower operation costs and without compromising safety. Concerning the complex requirements for fan systems or fan containments, composite materials are able to fully avail their high potential with regard to a significant weight reduction and a...

Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap.

BACKGROUND The fibrous cap of the atherosclerotic lesion is believed to be critical to stability because disruption of the cap is the final event leading to plaque rupture. We have, therefore, used expression arrays to define the phenotype of the cap and other plaque components. METHODS AND RESULTS To identify unique expression programs able to distinguish the smooth muscle of the cap from ot...

A Numerical and Experimental Investigation on Delamination Buckling Behavior in Laminated Composites under Compressive Load