Nucleus pulposus inhibits the axonal outgrowth of cultured dorsal root ganglion cells
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چکیده
منابع مشابه
Local application of nucleus pulposus induces expression OF P2X3 in rat dorsal root ganglion cells.
The P2X(3) receptor is a ligand-gated cation channel that is activated by extra cellular adenosine triphosphate (ATP) found in the dorsal root, trigeminal and nodose ganglia. It is one of the receptors transmitting nociceptive information of injuries and inflammation of the periphery by endogenous ATP released from damaged cells. The present study was performed in order to evaluate if there was...
متن کاملLow-concentration lidocaine rapidly inhibits axonal transport in cultured mouse dorsal root ganglion neurons.
BACKGROUND Axonal transport plays a critical role in supplying materials for a variety of neuronal functions such as morphogenetic plasticity, synaptic transmission, and cell survival. In the current study, the authors investigated the effects of the analgesic agent lidocaine on axonal transport in neurites of cultured mouse dorsal root ganglion neurons. In relation to their effects, the effect...
متن کاملDiethyldithiocarbamate, a superoxide dismutase inhibitor, inhibits axonal transport in cultured mouse dorsal root ganglion neurons
Background: Axonal transport is an important neuronal cell function, as it serves to supply neuron materials and conveys information. Therefore, any change in axonal transport expresses the state of neurons, and impairment of axonal transport precedes neuronal degeneration. Reactive oxygen species (ROS) and oxidative stress are implicated in neuronal damage and are an important pathology in neu...
متن کاملPb2+ blocks calcium currents of cultured dorsal root ganglion cells.
The divalent cation lead (Pb2+) blocks sustained and transient voltage sensitive calcium channel currents of cultured rat dorsal root ganglion cells. The IC50 for inhibition of the total peak current evoked by a step depolarization from -80 to 0 mV was 0.6 microM, compared to an IC50 of 2.2 microM for Cd2+. The current activated by a depolarization from -40 to 0 mV was inhibited by 50% by 1.0 m...
متن کاملEvaluation of Hyperalgesia and Histological Changes of Dorsal Root Ganglion Induced by Nucleus Pulposus.
UNLABELLED To evaluate the hyperalgesia and histological abnormalities induced by contact between the dorsal root ganglion and the nucleus pulposus. METHODS Twenty Wistar rats were used, divided into two experimental groups. In one of the groups, a fragment of autologous nucleus pulposus was removed from the sacrococcygeal region and deposited on the L5 dorsal root ganglia. In the other group...
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ژورنال
عنوان ژورنال: European Spine Journal
سال: 2000
ISSN: 0940-6719,1432-0932
DOI: 10.1007/s005860050002