Nucleotide Sugar Transporter SLC35 Family Structure and Function
نویسندگان
چکیده
منابع مشابه
Structure and function of nucleotide sugar transporters: Current progress
The proteomes of eukaryotes, bacteria and archaea are highly diverse due, in part, to the complex post-translational modification of protein glycosylation. The diversity of glycosylation in eukaryotes is reliant on nucleotide sugar transporters to translocate specific nucleotide sugars that are synthesised in the cytosol and nucleus, into the endoplasmic reticulum and Golgi apparatus where glyc...
متن کاملNucleotide-sugar transporters: structure, function and roles in vivo.
The glycosylation of glycoconjugates and the biosynthesis of polysaccharides depend on nucleotide-sugars which are the substrates for glycosyltransferases. A large proportion of these enzymes are located within the lumen of the Golgi apparatus as well as the endoplasmic reticulum, while many of the nucleotide-sugars are synthesized in the cytosol. Thus, nucleotide-sugars are translocated from t...
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possess a transport system for glucose of the facilitative diffusion type; these transporters allow the movement of glucose across the plasma membrane down its chemical gradient either into or out of cells. These transporters are specific for the D-enantiomer of glucose and are not coupled to any energy-requiring components, such as ATP hydrolysis or a HI gradient [1]. The facilitative glucose ...
متن کاملMolecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family.
Transport of the co-substrate UDPGA (UDP-glucuronic acid) into the lumen of the endoplasmic reticulum is an essential step in glucuronidation reactions due to the intraluminal location of the catalytic site of the enzyme UGT (UDP-glucuronosyltransferase). In the present study, we have characterized the function of several NSTs (nucleotide sugar transporters) and UGTs as potential carriers of UD...
متن کاملEvolution of the Apicomplexan Sugar Transporter Gene Family Repertoire
Apicomplexan protist parasites utilize host sugars transported into the parasite by sugar transporter proteins for use as an energy source. We performed a phylum-wide phylogenetic analysis of the apicomplexan sugar transporter repertoire. Phylogenetic analyses revealed six major subfamilies of apicomplexan sugar transporters. Transporters in one subfamily have undergone expansions in Piroplasma...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2019
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2019.08.002