Nucleotide excision repair and human syndromes

Nucleotide excision repair and human syndromes.

DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist that safeguard the genome from these deleterious consequences. Nucleotide excision repair (NER) removes a wide diversity of lesions, the main of which include UV-induced lesions, bulky chemical adducts and some forms of oxidative damage. The NER process involves the action of at least 30 proteins in a 'cut-and...

Mammalian nucleotide excision repair and syndromes.

Mammalian nucleotide excision repair and syndromes W. Vermeulcn*, J. de Boer*, E. Citterio*, A. J. van Gool*, G. T. J. van der Horst*, N. G. J. Jaspers*, W. L. dc Laat*, A. M. Sijbers*, P. J. van der Spek*, K. Sugasawa*, G. Weeda*, G. S. Winkler*, D. Bootsma*, J.-M. Egly-land J. H. J. Hoeijmakers. *Department of Genetics, Medical Genetics Centre, Erasmus University, P.O. Box I 738, 3000DR Rotte...

Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies.

INTRODUCTION THE DEVELOPMENT and maintenance of life has critically depended on the evolution of mechanisms that ensure genetic integrity and stability. DNA, the vital carrier of genetic information, is continually subjected to undesired chemical alterations. Numerous environmental or endogenous compounds and various types of radiation, such as X-rays and ultra-violet (UV) light, induce a wide ...

Prokaryotic nucleotide excision repair.

Nucleotide excision repair (NER) has allowed bacteria to flourish in many different niches around the globe that inflict harsh environmental damage to their genetic material. NER is remarkable because of its diverse substrate repertoire, which differs greatly in chemical composition and structure. Recent advances in structural biology and single-molecule studies have given great insight into th...

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