منابع مشابه
What makes Ran run?
Cloning confusion very cloning pronouncement has one guaranteed ingredient: controversy. This time, Atsuo Ogura (National Institute of Infectious Diseases, Tokyo, Japan) and Rudolf Jaenisch (Massachusetts Institute of Technology, Cambridge, MA) are duking it out. Ogura claims that most of the defects that Jaenisch has seen in his cloned mice were caused by the genetic instability of the embryon...
متن کاملRunning on Ran Nuclear Transport and the Mitotic Spindle
sol and GTP hydrolysis. In particular, nuclear import Far from being passive participants in the process of is accomplished for proteins bearing classical nuclear mitosis, chromosomes have an active and essential role localization signals (NLS) by a heterodimeric receptor in the assembly of spindles required for their accurate comprised of a Ran-GTP binding protein, importin b, division into th...
متن کاملNuclear transport factor p10/NTF2 functions as a Ran–GDP dissociation inhibitor (Ran-GDI)
The cytosolic nuclear transport factor p10/NTF2 is required for the translocation of karyophilic molecules through nuclear pores [1] [2] [3], and the small GTPase Ran is a key regulator of protein transport between the nucleus and cytoplasm [4] [5]. It has been reported that p10/NTF2 interacts directly and specifically with Ran-GDP but not with Ran-GTP [6]. The precise role(s) of p10/NTF2 in th...
متن کاملThe dynamic association of RCC1 with chromatin is modulated by Ran-dependent nuclear transport.
Regulator of chromosome condensation (RCC1) binding to chromatin is highly dynamic, as determined by fluorescence recovery after photobleaching analysis of GFP-RCC1 in stably transfected tsBN2 cells. Microinjection of wild-type or Q69L Ran markedly slowed the mobility of GFP-RCC1, whereas T24N Ran (defective in nucleotide loading) decreased it further still. We found significant alterations in ...
متن کاملNuclear Import of IkBa Is Accomplished by a Ran-Independent Transport Pathway
The inhibitor of kappa B alpha (IkBa) protein is able to shuttle between the cytoplasm and the nucleus. We have utilized a combination of in vivo and in vitro approaches to provide mechanistic insight into nucleocytoplasmic shuttling by IkBa. IkBa contains multiple functional domains that contribute to shuttling of IkBa between the cytoplasm and the nucleus. Nuclear import of IkBa is mediated b...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 1998
ISSN: 0002-9297
DOI: 10.1086/301990