"Nuclear Reprogramming" and "Epigenetic Reprogramming"
نویسندگان
چکیده
منابع مشابه
Epigenetic reprogramming and nuclear transfer
Nuclear transfer, also referred to as cloning, attracted public attention when the first mammal, the sheep Dolly, was cloned from an adult cell. In this review, we highlight some of the milestones reached in the 50 years following the first nuclear transplantations in frogs. We also address the problems associated with nuclear transfer and provide an survey on current stem-cell technology. In t...
متن کاملNuclear cloning, epigenetic reprogramming, and cellular differentiation.
The full-term development of sheep, cows, goats, pigs and mice has been achieved through the transfer of somatic cell nuclei into enucleated oocytes. Despite these successes, mammalian cloning remains an inefficient process, with a preponderance of reconstructed embryos failing at early- to mid-gestation stages of development. The small percentage of conceptuses that survive to term are charact...
متن کاملI-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer
Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
متن کاملNuclear reprogramming.
There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and pa...
متن کاملEpigenetic reprogramming in cancer.
The demonstration of induced pluripotency and direct lineage conversion has led to remarkable insights regarding the roles of transcription factors and chromatin regulators in mediating cell state transitions. Beyond its considerable implications for regenerative medicine, this body of work is highly relevant to multiple stages of oncogenesis, from the initial cellular transformation to the hie...
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ژورنال
عنوان ژورنال: Journal of Mammalian Ova Research
سال: 2004
ISSN: 1341-7738,1347-5878
DOI: 10.1274/jmor.21.97