منابع مشابه
I-12: Nuclear Reprogramming in Bovin Somatic Cell Nuclear Transfer
Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
متن کاملNuclear reprogramming.
There is currently particular interest in the field of nuclear reprogramming, a process by which the identity of specialised cells may be changed, typically to an embryonic-like state. Reprogramming procedures provide insight into many mechanisms of fundamental cell biology and have several promising applications, most notably in healthcare through the development of human disease models and pa...
متن کاملPluripotency and nuclear reprogramming.
Embryonic stem cells are promising donor cell sources for cell transplantation therapy, which may in the future be used to treat various diseases and injuries. However, as is the case for organ transplantation, immune rejection after transplantation is a potential problem with this type of therapy. Moreover, the use of human embryos presents serious ethical difficulties. These issues may be ove...
متن کاملNuclear reprogramming in cells.
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of another unrelated cell type. Early studies in frog cloning provided some of the first experimental evidence for reprogramming. Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming. Through these ...
متن کاملNuclear reprogramming in zygotes.
Nuclear reprogramming, the conversion of the epigenome of a differentiated cell to one that is similar to the undifferentiated embryonic state, can be facilitated by several methods, such as nuclear transfer, cell fusion, use of embryonic stem cell extracts, and more recently, by the introduction of exogenous transcription factors. Amongst these various strategies, somatic cell nuclear transfer...
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ژورنال
عنوان ژورنال: Development
سال: 2013
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.092049