Nuclear remodelling during viral infections

Nuclear Actin and Lamins in Viral Infections

Lamins are the best characterized cytoskeletal components of the cell nucleus that help to maintain the nuclear shape and participate in diverse nuclear processes including replication or transcription. Nuclear actin is now widely accepted to be another cytoskeletal protein present in the nucleus that fulfills important functions in the gene expression. Some viruses replicating in the nucleus e...

Procoagulant activity during viral infections.

The abundance of evidence suggest that inflammation of immune and non-immune cells may lead to an imbalance of the pro- and anti-coagulant state during viral infections. During systemic infections, the endothelium plays a critical role in regulating hemostasis, and severe imbalances of endothelial function and activation can contribute to organ failure. Viral infections may elevate plasma level...

Neutrophil Apoptosis During Viral Infections

Apoptosis, or programmed cell death, is a highly conserved cellular suicide mechanism. Apoptosis is critical to the effective resolution of inflammation, particularly in regulating the lifespan of neutrophils. Neutrophils are key components of the first line of defense against microorganisms. Thus, subversion of this critical host defense mechanism by pathogens can contribute to susceptibility ...

Immune functions during chronic viral infections

Chronic viral infections display a major health burden worldwide. Immune control of chronic viral infections requires a balanced interplay between immune activation promoting virus clearance and deactivation of antiviral immunity to prevent tissue damage. Our research is focused on identifying mechanisms regulating the balanced immune control of viral infections. Innate type I interferon produc...

Studies on Avian Viral Infections in Iran