Nuclear Receptor Signaling and Cardiac Energetics
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چکیده
منابع مشابه
Peroxisome Proliferator-Activated Receptors and Atherogenesis: Regulators of Gene Expression in Vascular Cells Nuclear Receptor Signaling in the Control of Cholesterol Homeostasis Nuclear Receptor Signaling and Cardiac Energetics
A large body of data gathered over the past couple of years has identified the peroxisome proliferator-activated receptors (PPAR) , , and / as transcription factors exerting modulatory actions in vascular cells. PPARs, which belong to the nuclear receptor family of ligand-activated transcription factors, were originally described as gene regulators of various metabolic pathways. Although the PP...
متن کاملNuclear Receptor Signaling and Cardiac Energetics PPARs and Atherogenesis: Regulators of Gene Expression in Vascular Cells Nuclear Receptor Signaling in the Control of Cholesterol Homeostasis
The heart has a tremendous capacity for ATP generation, allowing it to function as an efficient pump throughout the life of the organism. The adult myocardium uses either fatty acid or glucose oxidation as its main energy source. Under normal conditions, the adult heart derives most of its energy through oxidation of fatty acids in mitochondria. However, the myocardium has a remarkable ability ...
متن کاملNuclear Receptor Signaling Atlas (): hyperlinking the nuclear receptor signaling community
The nuclear receptor signaling (NRS) field has generated a substantial body of information on nuclear receptors, their ligands and coregulators, with the ultimate goal of constructing coherent models of the biological and clinical significance of these molecules. As a component of the Nuclear Receptor Signaling Atlas (NURSA)--the development of a functional atlas of nuclear receptor biology--th...
متن کاملPeroxisome Proliferator-Activated Receptors and Atherogenesis: Regulators of Gene Expression in Vascular Cells Nuclear Receptor Signaling in the Control of Cholesterol Homeostasis: Have the Orphans Found a Home? Nuclear Receptor Signaling and Cardiac Energetics
Cholesterol is essential for all mammalian cells. Cellular cholesterol requirements are met through de novo synthesis and uptake of plasma lipoproteins, homeostatic responses that are transcriptionally regulated by the sterol regulatory element-binding proteins (SREBPs). To prevent cytotoxicity attributable to accumulation of excess cholesterol, liver X receptors (LXRs) and the farnesoid X rece...
متن کاملNuclear Receptor Signaling: a home for nuclear receptor and coregulator signaling research
The field of nuclear receptor and coregulator signaling has grown into one of the most active and interdisciplinary in eukaryotic biology. Papers in this field are spread widely across a vast number of journals, which complicates the task of investigators in keeping current with the literature in the field. In 2003, we launched Nuclear Receptor Signaling as an Open Access reviews, perspectives ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000141774.29937.e3