Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor
نویسندگان
چکیده
منابع مشابه
Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces.
Steroid hormone receptors act to regulate specific gene transcription primarily as steroid-specific dimers bound to palindromic DNA response elements. DNA-dependent dimerization contacts mediated between the receptor DNA binding domains stabilize DNA binding. Additionally, some steroid receptors dimerize prior to their arrival on DNA through interactions mediated through the receptor ligand bin...
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Robert J.G. Haché, Joanne G.A. Savory and Yvonne A. Lefebvre Departments of Medicine, Biochemistry, Microbiology and Immunology, The Loeb Health Research Institute at the Ottawa Hospital, University of Ottawa, 725 Parkdale Ave., Ottawa, Ontario, Canada, K1Y 4K9 ______________________________________________________________________________________________________ 3 Correspondence: Robert J.G. Ha...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2017
ISSN: 1043-2760
DOI: 10.1016/j.tem.2017.04.001