Nuclear receptor coactivators and corepressors.
نویسندگان
چکیده
منابع مشابه
Nuclear receptor corepressors and PPARγ
The nuclear receptor corepressors NCoR and SMRT repress gene transcription by recruiting a histone deacetylase complex. Their roles in PPARgamma action have been controversial. Recent evidence, however, suggests that NCoR and SMRT repress PPARgamma-mediated transcriptional activity on specific promoters in the adipocyte. In addition, by repressing PPARgamma action, these corepressors inhibit th...
متن کاملNuclear receptor corepressors
The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins. The yeast-two hybrid screen for protein interactors has proven to be the key to the isolation and characterization of corepressors. This short...
متن کاملDirect interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.
The unliganded thyroid hormone receptor beta (TRbeta) represses the basal transcriptional activity of target genes, in part through interactions with the nuclear receptor corepressor (N-CoR). In this study we have identified a rather unexpected interaction between N-CoR and the nuclear receptor coactivator ACTR. We have demonstrated in vitro and in intact cells that N-CoR directly associates wi...
متن کاملExpression Levels of Estrogen Receptor-a, Estrogen Receptor-b, Coactivators, and Corepressors in Breast Cancer
Recent studies have indicated that a complex machinery of transactivation of target genes by estrogen or antiestrogen through estrogen receptor (ER) exists. However, the substantial roles of ER-b, coactivators, and corepressors in the development and progression of breast cancer remain to be elucidated. To obtain some clue to these roles, we screened the expression levels of ER-a, ER-b, coactiv...
متن کاملThe nuclear corepressors recognize distinct nuclear receptor complexes.
The thyroid hormone receptor (TR) and retinoic acid receptor (RAR) isoforms have the capacity to silence gene expression in the absence of their ligands on target response elements. This active repression is mediated by the ability of the corepressors, nuclear receptor corepressor (NCoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT), to recruit a complex containing his...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1996
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.10.10.9121485