Nuclear Positioning Requires a Tug-of-War between Kinesin Motors
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چکیده
منابع مشابه
Engineered Tug-of-War Between Kinesin and Dynein Controls Direction of Microtubule Based Transport In Vivo.
Bidirectional transport of membrane organelles along microtubules (MTs) is driven by plus-end directed kinesins and minus-end directed dynein bound to the same cargo. Activities of opposing MT motors produce bidirectional movement of membrane organelles and cytoplasmic particles along MT transport tracks. Directionality of MT-based transport might be controlled by a protein complex that determi...
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Intracellular transport is interspersed with frequent reversals in direction due to the presence of opposing kinesin and dynein motors on organelles that are carried as cargo. The cause and the mechanism of reversals are unknown, but are a key to understanding how cargos are delivered in a regulated manner to specific cellular locations. Unlike established single-motor biophysical assays, this ...
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ny cell therapy risks introducing mutated and possibly tumorigenic cells. Now results from Peter Stambrook (University of Cincinnati, Cincinnati, OH) and colleagues underline this concern for embryonic stem (ES) cells, which are one possible source for therapeutic cells. Stambrook constructed a cell line in which he could detect loss or mutation of a heterozygous marker gene. Loss (rather than ...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 2018
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.18.00499