منابع مشابه
Passenger proteins check in
D espite their name, the passenger proteins aren't just along for the ride during mitosis. They are busy helping control the attachment of spindle fi bers to the chromosomes and ensuring that the cell splits after the chromosomes part. INCENPs' many locations But it was the proteins' seemingly bizarre movements that fi rst caught the eye of William Earnshaw (now at the University of Edinburgh i...
متن کاملThe role of farnesylated nuclear membrane proteins
*Correspondence to: Jörg Großhans; Email: [email protected] Changes in nuclear morphology are observed in diverse developmental processes as well as in pathological conditions. Modification of nuclear membrane and nuclear lamina protein levels results in altered nuclear shapes, as it has been demonstrated in experimental systems ranging from yeast to human cells. The imp...
متن کاملActive Nuclear Import of Membrane Proteins Revisited.
It is poorly understood how membrane proteins destined for the inner nuclear membrane pass the crowded environment of the Nuclear Pore Complex (NPC). For the Saccharomyces cerevisiae proteins Src1/Heh1 and Heh2, a transport mechanism was proposed where the transmembrane domains diffuse through the membrane while the extralumenal domains encoding a nuclear localization signal (NLS) and intrinsic...
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The nuclear lamina is a scaffolding structure at the nuclear periphery and is required for maintenance of nuclear shape, spacing of nuclear pore complexes, organization of heterochromatin, DNA replication, and regulation of transcription factors. The lamina is formed by type V intermediate filament proteins, Aand B-type lamins, which assemble to form a meshwork of 10-nm filaments underneath the...
متن کاملIntegral membrane proteins specific to the inner nuclear membrane and associated with the nuclear lamina
We obtained a monoclonal antibody (RL13) that identifies three integral membrane proteins specific to the nuclear envelope of rat liver, a major 75-kD polypeptide and two more minor components of 68 and 55 kD. Immunogold labeling of isolated nuclear envelopes demonstrates that these antigens are localized specifically to the inner nuclear membrane, and that the RL13 epitope occurs on the inner ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2014
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3898