Nuclear fundamentals remain

Fundamentals of Nuclear Physics

Fundamentals of Nuclear Energy

A number of scientific discoveries regarding the nature of atoms and their characteristics were made over a relatively short period of time. These lead to the splitting of the atom and the realization that potentially large amounts of energy could be released in the fissioning of certain nuclides. Work on this was expedited in secret during the Second World War during which time the first nucle...

Transcription factories are nuclear subcompartments that remain in the absence of transcription.

Nascent transcription occurs at nuclear foci of concentrated, hyperphosphorylated RNA polymerase II (RNAPII). We investigate RNAPII localization, distal gene co-association, and Hbb locus conformation during inhibition of transcription. Our results show distal active genes remain associated with RNAPII foci and each other in the absence of elongation. When initiation is inhibited, active genes ...

Masters change, slaves remain.

Sex determination offers an opportunity to address many classic questions of developmental biology. In addition, because sex determination evolves rapidly, it offers an opportunity to investigate the evolution of genetic hierarchies. Sex determination in Drosophila melanogaster is controlled by the master regulatory gene, Sex lethal (Sxl). DmSxl controls the alternative splicing of a downstream...

Pediatric MLBL: challenges remain.

In this issue of Blood, Gerrard et al report the outcome and histologic classification of children and adolescents with mediastinal large B-cell lymphoma (MLBL), and highlight the need for new treatment strategies.