Nuclear export signals, and the molecular mechanism of nuclear export.
نویسندگان
چکیده
منابع مشابه
Human topoisomerase II α nuclear export is mediated by two CRM - 1 - dependent nuclear export signals
Recent investigations have elucidated several molecular pathways for the nuclear import and export of proteins (Kau and Silver, 2003; Weis, 2003) across transport passageways or nuclear pore complexes (NPCs) (Dreger, 2003). The NPC is a large (125 MDa) multimeric protein structure that perforates the nuclear envelope and channels proteins greater than 60 kDa into or out of the nucleus. The cons...
متن کاملHuman topoisomerase IIalpha nuclear export is mediated by two CRM-1-dependent nuclear export signals.
Resistance to chemotherapeutic drugs is a major obstacle in the treatment of leukemia and multiple myeloma. We have previously found that myeloma and leukemic cells in transition from low-density log phase conditions to high-density plateau phase conditions export substantial amounts of endogenous topoisomerase II alpha from the nucleus to the cytoplasm. In order for topoisomerase-targeted chem...
متن کاملNuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
Nuclear export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different cargoes. Previously we have shown that CRM1 binds NESs in both polypeptide orientations (Fung et al., 2015). Here, we show crystal structures of CRM1 bound to eight additional NESs which reveal diverse conformations that range from loop-like to all-helix, which occupy different extents of t...
متن کاملNuclear export signals and the fast track to the cytoplasm
One of the defining features of eukaryotic cells is the segregation of RNA biogenesis and DNA replication in the nucleus, separate from the cytoplasmic machinery for protein synthesis. Integration of the activities of the nucleus and cytoplasm requires the continuous transport of proteins, RNAs, and small molecules between these two compartments. Nucleocytoplasmic transport is mediated by nucle...
متن کاملNuclear export, enlightened.
T he physicist Richard Feynman once quipped that the key to solving or making significant progress on a scientific problem was to “find the open channel.” For the cell biological problem of nucleus-tocytoplasm transport, the literal open channels have long been known: the nuclear pore complexes (NPCs). However, in the metaphorical sense as well, recent work has significantly “opened” the NPC ch...
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ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1998
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.36.813