NT-proBNP

Human ProBNP and proBNP-derived Peptides (BNP and NT-proBNP)

Brain natriuretic peptide (BNP) is a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties (1, 2, 3). BNP belongs to a family of structurally similar peptide hormones that also includes atrial natriuretic peptide (ANP), C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a 17 amino acid ring structure with a disulfide bond between two cy...

NT-proBNP testing - a health economics brochure

Measuring NT-proBNP in small animal practice

The general veterinary practitioner has the difficult task of identifying, managing and advising on prognosis of heart disease, often with limited access to diagnostic equipment, or with limited experience in performing diagnostic procedures such as echocardiography. Financial resources are often limited. Furthermore pet owners may be reluctant to allow diagnostic investigation of animals they ...

Choosing cut-offs for NT-proBNP

Characterization of NT-proBNP in human urine.

BACKGROUND Urine amino-terminal probrain natriuretic peptide (NT-proBNP) concentrations may exclude the presence of heart failure and provide insight into renal clearance mechanisms for human NT-proBNP. We characterized the molecular forms of urine NT-proBNP detected by immunoassay. METHODS Urine from patients with heart failure was subjected to HPLC and analyzed using immunoassays specific t...