Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury
نویسندگان
چکیده
In this review, we discuss the possibility and feasibility of nuclear factor erythroid 2-related 2 (Nrf2) as a therapeutic target to minimize devastating effects brain injury. To complete comprehensive literature searches were conducted in MEDLINE, PubMed, Embase, PsycINFO databases for English scientific peer-reviewed articles through December 2022. This short review addressed different sources oxidative stress its on blood-brain barrier (BBB) dysfunction, mitochondrial damage, changes variety inflammatory molecules associated with central nervous system (CNS) At last, explained potential efficacy Nrf2 transcription reducing stress-mediated secondary damages after CNS The role CPUY192018, an inhibitor Nrf2-Keap1 protein-protein interaction protecting injured cells is given evidence Nrf2’s activating antioxidant genes. Overall, scope developing interventions pathophysiological conditions injury-induced free radical/inflammatory signaling acknowledged. has widespread application basic clinical neuroscience understanding treating disorders, including neurological diseases. development innovative strategies using Nrf2-inducing agents can be applied reduce complications TBI before advancing it posttraumatic disorder (PTSD).
منابع مشابه
miR-21, a potential therapeutic target of alleviating blood-brain barrier damage after traumatic brain injury
Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin 300052, China; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin 300052, China Laboratory of Neuro-Trauma, Tianjin Neurological Institute, Tianjin 300052, China Department of Neurosurgery, Tianjin Medical University General Hospital, Tian...
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1MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, UK 2Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, UK 3Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA 4Department of Pharmacology and Toxicology, Michigan State University...
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Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway over-activation can induce detrimental effects. An understanding of the mechanisms mediating Nrf2 inhibition in neurodegenerative conditions may there...
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ژورنال
عنوان ژورنال: Journal of Integrative Neuroscience
سال: 2023
ISSN: ['1757-448X', '0219-6352']
DOI: https://doi.org/10.31083/j.jin2204081