منابع مشابه
Novel treatments for osteoporosis.
Osteoporosis is a major health problem that affects 4 to 6 million women and 1 to 2 million men in the US, with an even larger number of individuals having osteopenia or decreased bone mineral density (BMD) (1). The most significant consequence of osteoporosis is osteoporotic fractures, which in 1995 resulted in health care expenditures in the US of $13.8 billion (2). Consequently, the preventi...
متن کاملTreatments for osteoporosis - looking beyond the HORIZON.
Bisphosphonates are an important option for the prevention of fractures in postmenopausal women. However, the complex instructions for the administration of oral bisphosphonates are inconvenient or unsuitable for many patients, and adherence to long-term therapy is poor.1 The introduction of oral regimens for administration once weekly and, recently, once monthly has been associated with improv...
متن کاملEffects of osteoporosis treatments on bone quality
to fracture. However, bones fracture for different reasons, so there are several different biomechanical definitions of bone fragility. One function of bones is to carry loads. Fractures occur when loads exceed the bone strength, so weakened bones should be considered fragile. For example osteoporotic vertebral bodies might fracture during normal daily activities like opening a window or rising...
متن کاملCurrent and potential future drug treatments for osteoporosis.
There has been a major interest in the drug treatment of osteoporosis and an increase in the number of drugs available in most countries. The ideal drug (one which increases or restores bone density and trabecular connectivity) is still not available. However, in patients with relatively preserved trabecular connectivity and moderately reduced bone density, several agents have shown substantial...
متن کاملEmerging treatments for postmenopausal osteoporosis – focus on denosumab
The pathway of the receptor activator of the nuclear factor kappaB ligand (RANKL), RANK and osteoprotegerin (OPG) plays a central role in coupling bone formation and resorption during normal bone turnover and in a wide spectrum of diseases characterized by disturbed bone remodeling, increased bone resorption and bone destruction (osteoporosis, Paget's disease of bone, rheumatoid arthritis [RA],...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2000
ISSN: 0021-9738
DOI: 10.1172/jci10584