Novel Strategies to Improve CAR-T Cells in Solid Tumors: Mini Review
نویسندگان
چکیده
Purpose: The paper reviews the obstacles that face CAR-T cells in solid tumors and suggested novel strategies to overcome these association with efficacy as well safety profile of cell therapy. Subjects Methods: This is a systematic review exploring improve tumors. Results: Several have been developed, including: 1) targeting multiple antigens; 2) improving trafficking into tumor tissues; 3) Preventing immunosuppression TME on by different approaches such blocking recruitment MDSCs or TAM TME, saving viability from exhaustion negative signals, enhancement persistence activity PD-1/PDL-1 pathway 4) designing prevent exhaustion; 5) inducing self T response tumor-bearing host escape enhance activity. Conclusions: Recent researches about therapy carries new hope for
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ژورنال
عنوان ژورنال: Journal of scientific research in medical and biological sciences
سال: 2022
ISSN: ['2709-1511', '2709-0159']
DOI: https://doi.org/10.47631/jsrmbs.v3i3.520