منابع مشابه
Novel and Familiar Stressors
OBJECTIVES : We examined the role that novelty plays in determining interactions between chronic and acute stress, when both the chronic and acute stressors emphasize emotional processing (i.e. stressful stimuli that do not present immediate threats to somatic homeostasis, and are processed primarily by limbic and forebrain circuits). METHODS : Rats were exposed to a chronic variable stress (CV...
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Various topologies for representing 3D protein structures have been advanced for purposes ranging from prediction of folding rates to ab initio structure prediction. Examples include relative contact order, Delaunay tessellations, and backbone torsion angle distributions. Here, we introduce a new topology based on a novel means for operationalizing 3D proximities with respect to the underlying ...
متن کاملStructural Characteristics of Novel Protein Folds
Folds are the basic building blocks of protein structures. Understanding the emergence of novel protein folds is an important step towards understanding the rules governing the evolution of protein structure and function and for developing tools for protein structure modeling and design. We explored the frequency of occurrences of an exhaustively classified library of supersecondary structural ...
متن کاملEstimating the prevalence of protein sequences adopting functional enzyme folds.
Proteins employ a wide variety of folds to perform their biological functions. How are these folds first acquired? An important step toward answering this is to obtain an estimate of the overall prevalence of sequences adopting functional folds. Since tertiary structure is needed for a typical enzyme active site to form, one way to obtain this estimate is to measure the prevalence of sequences ...
متن کاملFamiliar Object Salience Affects Novel Word Learning.
Children use the presence of familiar objects with known names to identify the correct referents of novel words. In natural environments, objects vary widely in salience. The presence of familiar objects may sometimes hinder rather than help word learning. To test this hypothesis, 3-year-olds (N = 36) were shown novel objects paired with familiar objects that varied in their visual salience. Wh...
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ژورنال
عنوان ژورنال: Structure
سال: 2002
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(02)00750-5