Novel Pentablock Copolymers as Thermosensitive Self-Assembling Micelles for Ocular Drug Delivery
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Novel Pentablock Copolymers as Thermosensitive Self-Assembling Micelles for Ocular Drug Delivery
Many studies have focused on how drugs are formulated in the sol state at room temperature leading to the formation of in situ gel at eye temperature to provide a controlled drug release. Stimuli-responsive block copolymer hydrogels possess several advantages including uncomplicated drug formulation and ease of application, no organic solvent, protective environment for drugs, site-specificity,...
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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or ...
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ژورنال
عنوان ژورنال: Advanced Pharmaceutical Bulletin
سال: 2017
ISSN: 2228-5881,2251-7308
DOI: 10.15171/apb.2017.003