Novel nanocapsule of α-lipoic acid reveals pigmentation improvement: α-Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application

Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats

Overproduction of α-Lipoic Acid by Gene Manipulated Escherichia coli

Alpha-lipoic acid (LA) is an important enzyme cofactor widely used by organisms and is also a natural antioxidant for the treatment of pathologies driven by low levels of endogenous antioxidants. In order to establish a safer and more efficient process for LA production, we developed a new biological method for LA synthesis based on the emerging knowledge of lipoic acid biosynthesis. We first c...

Amelioration of docetaxel/cisplatin induced polyneuropathy by α-lipoic acid

Docetaxel (Taxotere; Aventis, Strasbourg, France) is currently considered to be one of the most important anticancer drugs. It is a semi-synthetic agent derived from baccatin III extracted from renewable Taxus baccata needles, which binds to tubulin inducing its polymerization [1]. It inhibits cell replication and leads to apoptosis. Docetaxel has displayed significant antitumor activity agains...

Α-lipoic Acid Reduces Neurogenic Hypertension by Blunting

22 We previously reported that ACE2 compensatory activity is impaired by the 23 disintegrin and metalloprotease 17 (ADAM17) and lack of ACE2 is associated 24 with oxidative stress in neurogenic hypertension. To investigate the relationship 25 between ADAM17 and oxidative stress, Neuro2A cells were treated with Ang-II 26 (100 nM) 24 h after vehicle or α-lipoic acid (LA: 500 μM). ADAM17 expressio...

Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex

In recent years, the number of patients suffering from diabetes mellitus has been increasing worldwide. In particular, type 2 diabetes mellitus, a lifestyle-related disease, is recognized as a serious disease with various complications. Many types of pharmaceutics or specific health foods have been used for the management of diabetes mellitus. At the same time, the relationship between diabetes...