Novel insights into the innate immune response to non‐tuberculous Mycobacteria
نویسندگان
چکیده
منابع مشابه
Nontuberculous Mycobacteria Immune Reconstitution Syndrome
The prevalence of nontuberculous mycobacteria infection (NTM) in Sub-Saharan Africa is estimated to be less than 1%. NTM is often underdiagnosed or misdiagnosed as tuberculosis in patients who present with immune reconstitution syndrome (IRS) following initiation of antiretroviral treatment (ART). Immune reconstitution syndrome is common in patients who start ART with low CD4 counts and high HI...
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An array of homogeneous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis and other mycobacteria has been probed with a panel of glycan-binding receptors expressed on cells of the mammalian innate immune system. The results provide an overview of interactions between mycobacterial glycans and receptors that media...
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Neutrophils contain antimicrobial peptides with antituberculous activity, but their contribution to immune resistance to tuberculosis (TB) infection has not been previously investigated to our knowledge. We determined differential white cell counts in peripheral blood of 189 adults who had come into contact with patients diagnosed with active TB in London, United Kingdom, and evaluated them for...
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The mechanisms by which HBV establishes and maintains chronic infection are poorly understood. Although adult acquired HBV is generally cleared by a robust immune response, most individuals infected at childbirth or in very early childhood develop lifelong chronic infection. In addition, acute infections are unresolved in approximately 5% of individuals infected in adulthood. The host cell mech...
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NTM are bacteria with a lipid-rich, impermeable outer membrane that results in slow growth, antibiotic-resistance, disinfectant-resistance (e.g., chlorine), acid-tolerance, and propensity to stick to pipe surfaces. The lipid-rich outer membrane is the major determinant of their ecology as: (1) NTM grow slowly because they use a great deal of energy to make the long chain fatty acids in the oute...
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ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2011
ISSN: 0818-9641,1440-1711
DOI: 10.1038/icb.2011.86